Toxicology International

ORIGINAL ARTICLE
Year
: 2015  |  Volume : 22  |  Issue : 1  |  Page : 21--29

Terminalia chebula attenuates DMBA/Croton Oil-Induced oxidative stress and inflammation in Swiss albino mouse skin


Ferial Majed, Sana Nafees, Summya Rashid, Nemat Ali, Syed Kazim Hasan, Rashid Ali, Ayaz Shahid, Sarwat Sultana 
 Department of Medical Elementology and Toxicology, Faculty of Science, Section of Molecular Carcinogenesis and Chemoprevention, Jamia Hamdard (Hamdard University), Hamdard Nagar, New Delhi, India

Correspondence Address:
Sarwat Sultana
Department of Medical Elementology and Toxicology, Faculty of Science, Section of Molecular Carcinogenesis and Chemoprevention, Jamia Hamdard (Hamdard University), Hamdard Nagar, New Delhi- 110 062
India

Objective: The present study was designed to investigate underlying molecular mechanism for antitumorigenic potential of Terminalia chebula (TC) against chemically-induced skin tumorigenesis in Swiss albino mice. It is used as herbal medicine because it exhibits antioxidant, anti-inflammatory, and anticarcinogenic activity. However, the précised underlying mechanism remains to be elucidated. Materials and Methods: In light of the important role of nuclear factor-kappaB (NF-κB), cyclooxygenase-2 (COX-2), inducible nitric oxide synthase (i-NOS), ornithine decarboxylase (ODC), proinflammatory cytokines, oxidative stress in carcinogenesis, chemopreventive efficacy of TC against 7,12-dimethylbenz[a] anthracene (DMBA), and croton oil-induced 2-stage skin carcinogenesis was studied in terms of cytoprotective antioxidant enzymes activity, lipid peroxidation (LPO), inflammatory responses, and expression of various molecular markers in skin tissues. Results: We found that topical application of TC at dose of 30 mg/kg b. wt. mouse effectively suppressed oxidative stress and deregulated activation of inflammatory mediators and tumorigenesis. Histological findings further supported the protective effects of TC against DMBA/croton oil-induced cutaneous damage. Conclusion: The findings of the present study suggest that the chemopreventive effect of TC is associated with upregulation of endogenous cytoprotective machinery and downregulation of inflammatory mediators (interleukin (IL)-6, COX-2, i-NOS, ODC, and NF-κB).


How to cite this article:
Majed F, Nafees S, Rashid S, Ali N, Hasan SK, Ali R, Shahid A, Sultana S. Terminalia chebula attenuates DMBA/Croton Oil-Induced oxidative stress and inflammation in Swiss albino mouse skin.Toxicol Int 2015;22:21-29


How to cite this URL:
Majed F, Nafees S, Rashid S, Ali N, Hasan SK, Ali R, Shahid A, Sultana S. Terminalia chebula attenuates DMBA/Croton Oil-Induced oxidative stress and inflammation in Swiss albino mouse skin. Toxicol Int [serial online] 2015 [cited 2017 Mar 25 ];22:21-29
Available from: http://www.toxicologyinternational.com/article.asp?issn=0971-6580;year=2015;volume=22;issue=1;spage=21;epage=29;aulast=Majed;type=0